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That said, mild effects can occur in some people, especially when starting any new supplement: Temporary bloating or fullness (more common with collagen) Mild digestive discomfort if taken without enough water These are usually short-lived and can be reduced by: Taking supplements with adequate water Starting with recommended doses Choosing high-quality, well-absorbed formulations Using clinically formulated products from trusted brands helps minimize unnecessary reactions

2021;66:102912 Elsevier

Aging Cell 19(12):e13268

This protective effect may be achieved by enhancing the Tet enzyme (dioxygenase) and DNA methylation