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Advanced / Aggressive Protocol (3 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)

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These beneficial effects were shown in the counteraction of glaucoma (i.e., normalization of increased intraocular pressure, maintained retinal integrity, recovered pupil function), the counteraction of retinal ischemia, and the control of pupil function [110,111,112,113]