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Sensory Stimuli: Overwhelming sensory input, such as loud noises, intense lights, and strong odors, can act as a catalyst for migraine episodes

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Management of respiratory depression may include close observation, supportive measures, and use of opioid overdose reversal agents, depending on the patients clinical status (see OVERDOSAGE)

The latter shows the complexity of this topic as high throughput genetic screening was necessary, which requires high effort in terms of cost and interpretation and is therefore not suited for daily clinical practice ( To date there is no general recommendation regarding pre-emptive genotyping, even though doubling the first Tac dose after solid organ transplantation is recommend in known CYP3A5 expressors