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JS-K is reportedly activated by glutathione conjugation by glutathione transferase (GST), but the scope of activities among the numerous members of the GSTome is unknown

doi: 10.3389/fncel.2025.1601366 Received 27 March 2025 Accepted 10 June 2025 Published 04 July 2025 Volume 19 - 2025 Edited by Marco Cambiaghi, University of Verona, Italy Reviewed by Enoch Luis, National Council of Science and Technology (CONACYT), Mexico Mingzi Zhang, University of Southern California, United States Updates Copyright 2025 Bessetti and Litwa

[DOI] [PMC free article] [PubMed] [Google Scholar] 317.Choo J-D, Lee J-S, Kang J-S, Lee H-S, Yeom J-Y, Lee Y-H

Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8