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Common challenges for any systematic review of studies investigating autism spectrum disorders include changes in the criteria for diagnosis and laboratory methodology, the emphasis of early studies on individual metabolites rather than metabolic systems (e.g

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Petersburg Institute of Bioregulation and Gerontology, Epitalon has been studied as a research tool for investigating telomerase enzyme activity, hTERT transcriptional regulation, telomere biology, and chromatin state dynamics in controlled in-vitro experimental systems