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In macro-autophagy, double-membraned organelles of the autophagosome contain cellular constituents through various steps, which are then fused to lysosomes to enable degradation
The specific goal at the start of these efforts was to create a short list of attractive Food and Drug Administration-approved drugs that could be tested rapidly in clinical trials without requiring a drug development effort. That effort was buttressed by the development of a streamlined infrastructure for conducting Phase I and II clinical trials Meanwhile, the BBRAIN repository provided an infrastructure component which allowed for a more efficient exploration of the mechanisms behind GWI, the identification of biomarkers, etc
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