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Well it should matter

What remains unknown Despite encouraging data, genuine unknowns exist: Effects beyond 6-9 months of continuous use have not been formally studied in animals or humans

discussion 1111-2, 2001

2, in c-Met signaling, overexpression of the c-Met receptor and HGF results in sustained PI3K/Akt/mTOR and MAPK signaling activation through Gab1 and mutation of MET kinase domain, which are associated with therapy resistance [87]