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Intracellular GSH is compartmentalized within the nucleus, mitochondria and endoplasmic reticulum, all of which constitute separate redox pools that are distinct from the cytoplasmic pool in terms of distribution of the GSH and GSSG forms, their redox potential and their control of cellular activities

Sildenafil in term and premature infants: a systematic review

The use of antioxidants or immunosuppressant drugs to reduce ROS production is already widely used in clinical practice ( Origin of Oxidative Stress and Vulnerable Antioxidant System: Mechanistic Factors in Vitiligo Development It is well known in vitiligo patients that dramatic imbalance between the oxidant system (high) and EAS (deficient) leads to a predominant state of OS (Schallreuter, 2014)

PMID 3094341