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Human gut microbiota is composed of five predominantly phyla of bacteria: Firmicutes (60 to 80%), which includes the classes of Clostridia , Bacilli and Negativicutes , the Bacteroidetes (20 to 40%, including Flavobacteria , Bacteroidia , Sphingobacteria and Cytophagia , the Verrucomicrobia, the Actinobacteria and a lesser extent of Proteobacteria