Currently, based on evidence from neuroimaging, postmortem studies, and cerebrospinal fluid testing, BBB dysfunction has been recognized as an early biomarker of neurodegenerative diseases (Yuan, et al
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J Immunol 171(7):38633871 Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
(senior investigator, Laboratory of Asthma and Lung Inflammation, NHLBI), are conducting basic and clinical research on asthma, including a longitudinal observational study of severe asthma, which involves an overnight sleep study