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While agents like DFP and NAC demonstrate favorable BBB penetration, their systemic effects on iron metabolism raise concerns: iron chelators can induce unintended iron deficiency in peripheral tissues, while antioxidants may disrupt physiological redox balance, highlighting the need for brain-targeted delivery to minimize off-target effects

Furthermore, repeated assessment can provide a learning effect which can reduce the diagnostic capacity in PHES [89]

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Just because you consume carnitine doesn't mean that your body weight magically drops and your physical performance improves without changing any other part of your diet or lifestyle