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The etiology of goiter is complex and can occur in individuals with euthyroid, hyperthyroid, or hypothyroid states (Knobel 2016)

However, for B12, if any part of that complex digestive process is compromised especially the intrinsic factor or the absorption sites in the intestine then a significant portion of the B12 from a tablet might never reach your bloodstream

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Cerebrospinal fluid inflammatory cytokine aberrations in Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis: a systematic review and Meta-analysis