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Metabotropic Receptors Metabotropic glutamatergic receptors (mGluR)[homodimers], which are mainly distributed in corticolimbic areas, can be broadly divided into three categories according to their structures, ligand recognition profiles and coupling to cellular transduction systems: group I (mGluR1 and 5) receptors, group II (mGluR2 and 3), and group III (mGluR4, 6,7 and 8) (32)

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The research reveals that GHK-Cu modulates the NAD-dependent deacetylase sirtuin-1 (SIRT1) and the signal transducer and activator of transcription 3 (STAT3) signaling pathway