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If you stop suddenly: You might notice rebound dullness or breakouts (especially if skin was already sensitive) Oxidative stress can spike temporarily, especially if theres no antioxidant support from diet or skincare If you taper: Your body has a chance to adjust its GSH homeostasis more gently You can monitor changes and compensate with diet, skincare, or other supplements A lot of U.S.-based functional medicine docs recommend a cycling approach on for 3 months, off for 1

Moreover, further endothelial maintenance, mediated by continued VEGF signaling, and additional growth factor interactions (insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor (PDGF)) all promote vascular remodelling and luteal maintenance (77)

You may want to consult a functional medicine practitioner to come up with a protocol tailored to you

A patient who hasn't had that conversation isn't receiving appropriate care, regardless of where they're sourcing their sermorelin