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Trials continue even after approval

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PubMed, Custodio, Hipolito M., Raul Harari, et al

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In conclusion, we revealed novel structurefunction relationships of glutaredoxins, gained insights regarding the enzymatic conversion of glutathione- and non-glutathione disulfide substrates, and identified two distinct substrate interaction sites that include a scaffold residue and the conserved dual activator Lys105 in ScGrx7 and Lys26 in PfGrx

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An overview of current and future therapeutic strategies is provided in Table 2

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