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Unlike testosterone-based approaches, PT-141 acts centrally on melanocortin receptors (MC3R, MC4R) in the brain, influencing desire through dopaminergic pathways rather than peripheral blood flow

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Firstly, evidence from systematic reviews has shown that aerobic training can significantly enhance male erectile function [161], which may be related to mechanisms such as exercise reducing oxidative stress, increasing the production of lactic acid, NO, and cortisol, and raising total testosterone levels [162]

The combination of low NADPH concentration and high oxidative stress may lead to the progression and pathogenesis of atherosclerosis [48]