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People opposing these peptides inclusion on the list argued that little has changed since the FDA prohibited compounding pharmacies from dispensing these seven peptides in 2023

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( Unfortunately, this symptom of B12 deficiency overlaps with symptoms related to diabetic neuropathy nerve damage caused by high blood sugar that can cause pain and numbness in the extremities ( People with diabetes taking metformin are at a higher risk of developing B12 deficiency because this medication can reduce vitamin B12 absorption in the body ( So, a B12 deficiency could be misdiagnosed as peripheral neuropathy in people with diabetes

These peptides cannot legally be compounded into prescription medications and typically have less clinical evidence and regulatory oversight than FDA-approved drugs and are sold outside traditional medical channels