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Conclusion: Despite a low burden of established CVD, young ESUS patients harbored pathology in the vascular aging measures

The experimental animal, properly identified by its weight number, should be securely restrained by an assistant, positioning the animal with its head downward and abdomen upward

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It is important to note the regions of the brain that are more susceptible to the changes in BBB integrity as regions like the hippocampus and amygdala are heavily affected in neurodegenerative disease as they are vital for long-term memory and processing emotions and behavior