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In rodent-based investigations, administration of BPC-157 was associated with attenuation of inflammatory changes and improved structural outcomes in experimental models of adjuvant-induced arthritis

Due to its unusual structural stability and resistance to degradation in acidic environments, BPC-157 has attracted attention in experimental models studying vascular repair, inflammatory modulation, and soft tissue regeneration

Enzymes and inhibitors Deacetylation experiments were carried out using recombinantly expressed and affinity purified human sirtuin deacetylases SIRT1 (aa 225-664, N-terminal His 6 -tag), SIRT2 (aa 50-356, with N-terminal GST-tag or N-terminal His 6 -tag), SIRT3 (aa 118-399), SIRT5 (aa 34-302) and commercially obtained SIRT6 (full length, C-terminal His 6 -tag, Sigma Aldrich, cat no