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The endocrinologist or weight management specialist prescribing tirzepatide may not be aware of autoimmune disease nuances, while the rheumatologist may not be familiar with GLP-1 receptor agonist pharmacology

When a generalized and severe stage of inflammation is achieved, patients may develop sepsis, a life-threatening condition [124]

351,352 Lipotoxicity in Schwann cells results in cell dysfunction and death through mechanisms involving endoplasmic reticulum stress, mitochondrial dysfunction, and increased oxidative stress