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Monozygotic twin studies, which allow an assessment of the epigenome (gene x environment) independent of underlying genomic sequence mutations, showed high discordance rates and related epigenetic changes [14] in monozygotic twins discordant for psychiatric illnesses

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J Exp Bot 57:16851696 Schafer FQ, Buettner GR (2001) Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple