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Statistics Experiments were planned as 2 2 factorial designs, with data subject to mixed linear model analysis in R (version 4.2.1) and tests for the impact of NMN treatment within chemotherapy or vehicle control calculated by estimated marginal means using base R and the package emmeans (version 1.8.0), with p -values then subject to a Bonferroni correction for multiple comparisons

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The following is the typical dosing schedule for weeks 5-16: Weeks 5-8: 0.5 mg (semaglutide) / 0.5 mcg (vitamin B12) once weekly Weeks 9-12: 1.0 mg (semaglutide) / 0.5 mcg (Vitamin B12) once weekly Weeks 13-16: 1.7 mg (semaglutide) / 0.5 mcg (Vitamin B12) once weekly Weeks 17 onwards: 2.5 mg (semaglutide) / 0.5 mcg (Vitamin B12) once weekly, if further weight loss is required