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Tumor cells activate multiple carcinogenic pathways, leading to increased expression of transporters and metabolism-related enzymes, which in turn results in enhanced uptake of glutamine by tumor cells and massive consumption of glutamine in the TME [7, 23]

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In the vasculature, cuproptosis directly induces EC death and drives VSMCs toward a pro-inflammatory synthetic phenotype

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, , , L , : , , - 4

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The second study used direct sequencing to look at Sapap3 mutations in OCD patients with and without trichotillomania

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