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This localized depletion is strongly correlated with increased ventricular lactate, pointing to severe neuroinflammation, an overwhelmed central nervous system antioxidant network, and a direct physiological explanation for the profound cognitive dysfunction and "brain fog" experienced by patients

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It is because the adverse effects (such as anaphylaxis, thromboembolism, and pancreatitis) of L-asparaginase may outweigh the benefits [80]