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IGFBP-4 is specifically degraded by the metalloproteinase PAPP-A (Pregnancy Associated Plasma Protease -A) produced by the placenta as well as bone and ovary

The peptide inhibited hyperglycemia-induced epithelial-mesenchymal transition (EMT) and downregulated fibrosis-related genes, preventing the subretinal fibrosis that represents end-stage proliferative diabetic retinopathy

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The STEP programme clinical trial further looked at the benefits of semaglutide such as delayed gastric emptying in women with polycystic ovary syndrome (PCOS), which is the most common endocrine disorder in women of reproductive age, and obesity, as well as healthier eating habits, better portion sizes and overall less food cravings