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Vitamin E and Cardiovascular Disease

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Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation

This enzyme not only exhibits phosphatase activity, dephosphorylating thiamine phosphates in the lumen, but may also transphosphorylate extracellular thiamine to intracellular thiamine monophosphate (ThMP), at the expense of intracellular phosphate donors such as beta-glycerophosphate or creatine phosphate (101)