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Inhibition of DDX3X disrupts the DDX3X--catenin axis and the non-homologous end joining (NHEJ) DNA damage repair pathway [23]

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To overcome the above-mentioned hurdles of intranasal drug delivery, peptides and proteins can be modified to increase their membrane permeability and stability, by supplementing the drug with enzyme inhibitors that perturb the pseudo-first-pass effects (Pires et al., 2009)