File:Chlorambucil glutathione From Wikimedia Commons, the free media repository Size of this preview: 960 349 pixels
Once depleted, cells lose their ability to neutralize reactive oxygen species, defend against ferroptosis, support proper iron metabolism, and maintain immune and neurological function
To determine the activity and at the same time the cellular level of oxidative stress, it is necessary to assess specific biomarkers, namely: Superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant capacity, malondialdehyde, low-density lipoprotein (LDL)-oxidized, and anti-oxidized LDL antibodies
We expect in the near future growing recognition of GSH involvement, by S -glutathionylation and/or by the thiols redox state shift, not only in the induction of ATG and/or apoptosis, but also in the modulation of activities of molecular/transcription factors such as NEF2L2, PGC1, and p53 that by inducing the antioxidant defense and assuring mitochondrial homeostasis could block both processes
