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Following structural damage and functional impairment of the muscle tissue, myofibrillar rupture and extravasation of intracellular proteins such as myoglobin, creatine kinase (CK), and lactate dehydrogenase (LDH), into the extracellular medium, trigger the local inflammatory response [47, 50,51,52]

Injections provide the advantage of better bioavailability by avoiding enzymes in the gastrointestinal tract

Instead of mimicking GHRH and acting on its receptors in the brain, ipamorelin acts as a go-between (1)