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Within two months, my GERD was gone, and I was off the meds for good. Lisa R., 45, Florida My energy levels were in the gutter and my mood swings were taking a toll on my life

Discussion The BBB poses a significant impediment to drug delivery, with over 98% of pharmaceutical agents unable to efficiently traverse it, thereby diminishing their therapeutic efficacy in treating various neurological disorders, including neurodegenerative diseases 35

Despite its therapeutic potential, current evidence is limited by methodological gaps, preclinical inconsistencies and weak clinical evidence (no large-scale randomized controlled trials [RCTs])

preclinical evidence only