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Dilution Errors Incorrect dilution ratios can produce solutions with problematic osmolarity or pH that cause adverse effects upon administration

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We recommend avoiding the treatment if you are pregnant, breastfeeding, or have active skin infections or open wounds

Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)