Importantly, the IGF-1R is also critical for the increased expression of StAR under FSH stimulation, which is required for mitochondrial transport of cholesterol for the first step of sex steroid synthesis, pregnenolone production (60)
Kluck R, Muller S, Jagodzinski C, Hohenfellner K, Buscher A, Kemper MJ, Oh J, Billing H, Thumfart J, Weber LT, Acham-Roschitz B, Arbeiter K, Tonshoff B, Hagenberg M, Kanzelmeyer N, Pavicic L, Haffner D, Zivicnjak M (2022) Body growth, upper arm fat area, and clinical parameters in children with nephropathic cystinosis compared with other pediatric chronic kidney disease entities
This consideration affects protocol design and subject selection in research settings
Use your CP + HA combo diligently (whether it's daily or several times a week, based on your skin's tolerance)