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Body composition in DIO mice with/without NNMT inhibition showing reduced WAT mass with preserved lean mass relative to diet-matched controls [1,3,4]

Shaking can cause mechanical stress that damages the delicate peptide chains, potentially denaturing them and rendering them ineffective

Route/evidence mismatch: the pivotal mouse study tested subcutaneous injection at a fixed research dose (20 mg/kg, three times daily) the oral capsule use that is actually sold and discussed commercially has not itself been directly tested in that published research

As I said, I think that's an open question, but open to hearing about any research which would shed light on that