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Refinement can include an enrichment of animals environment, such as game or reward which can improve overall well-being 4,5 and the introduction of endpoints that allow humans to assess animal suffering

Healthcare professionals emphasise that sustainable weight management requires long-term commitment and that medications, when used, should be part of a comprehensive treatment plan with regular monitoring for efficacy, side effects, and overall health outcomes

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H 2 O 2 -induced leaf cell death and the crosstalk of reactive nitric/oxygen species