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The benefits claimedreversal of aging, improved cognition, enhanced metabolismremain unproven in controlled human trials

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For instance, athletes often have lower resting heart rates due to their enhanced cardiovascular efficiency, while individuals experiencing chronic stress may notice elevated heart rates even at rest

Senescence is a state in which a cell permanently exits the cellcycle (no longer divides) in response to stress such as DNA damage, telomere shortening, oncogene activation, oxidative stress, or replicative exhaustion