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Blood NADs and Glutathione Metabolites are Perturbed in Various Diseases To explore whether the redox pools were modified by chronic age-related diseases, we examined blood NAD and glutathione metabolites across 11 different diseases, including various cancer types, diabetes (Type II) and neurodegenerative diseases (Parkinsons and Alzheimers)

High l-arginine concentration reduced the gene expression for cationic amino acid transporter (SLC7A1) but it left unaffected for protein arginine methyltransferases (PRMT1, PRMT3 and PRMT5)

L-Citrulline's role: L-Citrulline is converted to L-Arginine in the kidneys via argininosuccinate lyase

If your levels are in the intermediate range, your doctor may also test your levels of MMA and homocysteine