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Factors such as severe thrombocytopenia, serum aspartate aminotransferase levels exceeding 60 U/L and the presence of diabetes have been identified as independent predictors associated with pruritus in cirrhosis (21)

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Oxidized Prdx2 forms an interchain disulfide, which is recycled by thioredoxin and thioredoxin reductase, and this requires reducing equivalents from NADPH

These results are very similar to those found in this study, where a correlation can be observed (Figure 2a and Supplementary Tables S1, S2) between the increase in pressure (up to 166 bar), the increase in solvent density and the enhancement of oil solubility in Sc-CO