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B., de Carvalho, M.,

In any case, the structure of the Co II -bound NiCo riboswitch reveals four Co II binding sites that likely nucleate formation of a four-way junction stabilized by a network of contacts that may explain how cooperative binding of Co II ions to adjacent sites might be achieved (Figure 22D)

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This trial did indeed show a significant inhibition of radiation-induced cell growth delay at 40 mg/kg oral dose, and a borderline inhibition at 20 mg/kg