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Katarzyna Otulak-Kozie, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In controlled physiological concentrations, ROS perform the role of essential signaling molecules that modulate various biological processes like cell proliferation, immune response, and apoptosis [26]

Glutathione binds to and neutralizes oxidative compounds such as carbon radicals, hydroperoxides, superoxide, nitric oxide, peroxynitrites, and lipid peroxides.* [3] Mitochondria are the energy-producers of each cell and depend on glutathione for protection.* When free radicals damage mitochondria, their activity becomes sluggish, and they can contribute to further mitochondrial oxidation

F., Jimenez-Del-Rio, M