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The success of pharmacological agents in normalizing central gain metrics, such as the auditory brainstem response wave V/I amplitude ratio, and reducing tinnitus behavior provides a benchmark for what cell therapies might need to achieve (Lu et al., 2021)

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In preclinical research models, it has been studied extensively for its involvement in angiogenesis (new blood vessel formation), fibroblast activity and collagen synthesis, growth factor modulation (including VEGF and EGF pathways), connective tissue signaling in muscle, tendon, and ligament models, gastrointestinal mucosal integrity, and inflammatory cytokine modulation