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Pharmacokinetics of 1 and 2 in vivo: intraperitoneal administration Chemicals and reagents HPLC-grade water was prepared by an in-house PURELAB Option filtration system (Elga lab water solution, UK)

GSTs conjugate 4HNE to GSH, and the corresponding glutathionyl-4-HNE (GS-HNE) is actively transported out of cells via RLIP76, a multifunctional membrane transporter for GSH-conjugated compounds, and/or MRPs (multidrug-resistance proteins