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Extracellular SOD has also been shown to decrease in human OA cartilage, suggesting that extracellular SOD also plays a key role in regulating ROS in cartilage (Regan et al., 2005)

Genome-wide methylation analyses of samples collected from the same diabetic patients 1617 years apart revealed that key genomic loci associated with diabetic complications of DNA methylation persist over time

However, methotrexate therapy requires careful monitoring due to its potential for adverse effects, particularly hepatotoxicity (Malaviya 2016