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Differential expression of genes involved in protein folding, quality control, and ER-associated degradation suggests increased proteotoxic stress or an adaptive reinforcement of protein quality control mechanisms

3xTg mice have consistently been shown to have impairments in hippocampal-dependent tasks such as Barnes Maze and NOR with memory deficits becoming apparent as early as 4-6 months of age and growing more severe with increasing age 13,59

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The C-terminal lysine carries an amide cap, conferring resistance to carboxypeptidase degradation