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doi: 10.3389/fbioe.2025.1729166 Received 21 October 2025 Revised 01 December 2025 Accepted 17 December 2025 Published 15 January 2026 Volume 13 - 2025 Edited by Ling Wang, Dalian Medical University, China Reviewed by Nicola Alessio, University of Campania Luigi Vanvitelli, Italy Yesuf Adem Siraj, Bahir Dar University, Ethiopia Updates Copyright 2026 Hu, Li, Hu, Shan, Tang, Jiang, Yi, Chen, Jin, Wang and Wang

(Endocrinology, 1998) published pivotal research establishing ipamorelin's selectivity profile among GHS-R agonists

Research by the group indicates that this enzyme activity enhances dopamine levels by regulating ascorbic acid homeostasis

Ipamorelin, acting as a selective ghrelin receptor agonist, complements this effect by promoting controlled GH release without significantly influencing appetite or cortisol levels