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In particular, we show that GTP-binding triggers interhelical interactions and subsequent anticlockwise motion of nucleotide-binding domain (NBD) involving the Rossmann folds that eventually close the catalytic cleft

Chemical protecting groups, such as Fmoc (9-fluorenylmethoxycarbonyl), shield specific areas of the amino acids to ensure they connect in the exact sequence desired, preventing unintended side reactions

With regard to possible future action, we will continue to monitor the claims data for resolution of the potential coding issues identified by the requestor