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Incorporating in vivo pharmacokinetic data or clinical evidence would enhance scientific rigor

PubMed Guyton JR, Fazio S, Adewale AJ, Jensen E, Tomassini JE, Shah A, Tershakovec AM

273 In malignant gliomas, BCAT c gene expression has been reported to be positively correlated with M2-type macrophages and Treg markers, 274 and GBM cells with high BCAT c expression can excrete BCKAs through monocarboxylate transporter 1 (MCT1)

The Established group showed significantly greater dACC glutamate deficit than the Recent group which was not accounted for by lifetime exposure to antipsychotic drugs or by their greater CRP or IL-6 levels nor was the deficit associated with glutathione depletion