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Jan 2024;49(1 Pt B):102166

Animal studies report biological activity after oral administration, especially in gastrointestinal models, which suggests potential local effectiveness

Although amelioration of penile deformity was not examined in an RCT comparing shock wave therapy alone with shock wave therapy plus PDE5Is, other investigators drew the conclusion that continuous therapy of PDE5Is may be a candidate in treatment of PD based on the significant improvement of observational parameters ( Intralesional Medication Intralesional injection could deliver the agents into the pathological site with relative high concentration and avoid systemic side effects where possible

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