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Clinical evidence for topical application includes studies using 50-100 mg/mL solutions with 5-aminolevulinic acid applied daily for 6 months

Pfizer-BioNTech Active ingredient mRNA coding for a form of the spike protein of SARS-CoV-2 Lipids (fats) (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) 2[(polyethylene glycol)-2000]- N,N-ditetradecylacetamide 1,2-distearoyl-sn-glycero-3-phosphocholine cholesterol Salts potassium chloride monobasic potassium phosphate sodium chloride dibasic sodium phosphate dihydrate Other tromethamine tromethamine hydrochloride sucrose Moderna Active ingredient mRNA coding for a form of the spike protein of SARS-CoV-2 Lipids (fats) SM-102 (Learn more about this ingredient) polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG] cholesterol 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC] Salts sodium acetate Other tromethamine tromethamine hydrochloride acetic acid sucrose Johnson & Johnson (Janssen) Active ingredient Recombinant, replication-incompetent adenovirus type 26 expressing the SARS-CoV-2 spike protein Salts sodium chloride trisodium citrate dehydrate citric acid monohydrate Other ethanol polysorbate-80 2-hydroxypropyl--cyclodextrin (HBCD) Were tromethamine and tromethamine hydrochloride, sometimes called tris, added to the COVID-19 vaccines to prevent heart attacks