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doi: 10.1016/j.biopha.2023.114851

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In the loading dose group, daily intranasal cobalamin administration led to a rapid rise in total serum vitamin B12 levels, increasing from a median of 230 to 1090 pmol/L within two weeks

Given the predominance of capillaries in the brain's vasculature, their significant role in vascular resistance, and the extensive review of CBF control by smooth muscle cells (SMCs) elsewhere [54], this discussion focuses on capillary-based CBF regulation [26]