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None of these questions can be considered resolved at the Phase 2 stage, and the glucagon axiss effects on resting heart rate in particular are exactly the kind of signal that only a large, long cardiovascular-outcomes trial is powered to characterize

Signaling pathways implicated in fibrosis in other contexts, such as the Wnt/-catenin, Hedgehog, and Rho/ROCK pathways, may also be involved in endometriosis [112]